Nutraceuticals have historically been seen as natural and safe supplements that have the potential to prevent illness, compensate for prescription medications, supplement for a bad diet, and boost overall health and well-being. At the moment, a number of nutraceuticals products are available on the market, the majority of which are antioxidants and probiotics. Because most nutraceutical items are designed for oral consumption, questions about their formulations, bioavailability, and/or location-specific delivery have arisen in recent years. This chapter covers the various pathways and sustained release mechanisms for active agents release from nutraceuticals release systems. The controlled release devices are mostly composed of polymers or polymer-derived nanoparticles. The physical methods are highlighted here to provide a brief idea of how the system works. The physical mechanisms involve diffusion, osmosis, erosion, degradation, and stimuli responsiveness. The kinetics of the release profiles are also giving sophisticated information regarding time-dependent release behavior. The release tuning and degree of encapsulation efficacy of active agents are also discussed here. As a whole, this charter will provide an idea of not only the release mechanisms but also the typical materials used for these purposes.