The economic and functional benefits of early and intensive rehabilitation based on differential learning (DL) are increasingly recognized in stroke recovery. This chapter delves into the innovative application of DL in the rehabilitation of individuals who have experienced a stroke. It begins by highlighting the growing burden of stroke and the urgent need for effective, adaptable rehabilitation strategies. DL, with its foundations in variability and adaptability, is presented as a promising alternative to traditional, repetition-based methods commonly used in both occupational and physical therapy. The chapter provides detailed protocols, variations, and practical examples to illustrate how DL can enhance motor learning, improve functional recovery, and better address the individual needs of patients. Additionally, the integration of DL into clinical practice is discussed, emphasizing its potential to optimize outcomes for stroke patients while reducing long-term healthcare costs. By offering a comprehensive framework, this chapter equips healthcare professionals with the knowledge to adopt and apply DL principles effectively in stroke rehabilitation.