Donald Trump’s “America First” foreign policy was explicitly framed as a shift toward national sovereignty and economic protectionism, but the forces that shaped its trajectory remain a subject of debate among scholars and policymakers. This chapter examines how economic, social, and historical factors influenced the development of this policy, even though these underlying dynamics were often overshadowed by political rhetoric. We explore the long-standing relationship between the United States and European powers, tracing how American foreign policy evolved to establish the nation as a global leader. Historically, the United States engaged in multilateral diplomacy and international alliances, but Trump’s America First policy marked a departure from those traditions, prioritizing bilateral trade deals, deregulation, and a reassertion of US economic dominance. America First was central to Trump’s broader Make America Great Again (MAGA) movement, rooted in a vision of restoring past US influence and authority. By moving away from established diplomatic frameworks, the policy signaled a reversal in America’s approach to global leadership. This chapter assesses the implications of that reversal, questioning whether it redefined US strategic priorities or merely reinforced a more transactional and isolationist stance in international relations.