The synergy between industry and technology entrepreneurship has driven a new market order of co-existence in entrepreneurial and social development, which has established a symbiosis between innovative start-ups and large corporations in manufacturing cost-effective innovative products with the potential of global branding and marketing to serve the changing consumer preferences. The chapter discussed the digital path to business resilience using AI, ML, and technology-based design thinking brings together leading technopreneurs, representatives of public and private sector organizations to coordinate mutual techno-economic growth.