This chapter examined the impact of strengthening disruptive innovation and business performance in Africa: Insights from pro-growth small businesses. The study employed a descriptive quantitative survey research approach. Primary data was collected via a methodical, closed-ended online survey. The study’s population, or sample size, consists of 282 small business owners and managers in southwest Nigeria. The data was analyzed using the purposive samples technique and multiple regression analysis. The results of the study show that strengthening disruptive innovation and business performance in Africa: Insights from pro-growth small businesses are significantly positively correlated (r = 0.52, p value < 0.05, Sig.000). Additionally, market competition has a significant impact on business performance (β = is 0.518, p value < 0.05, Sig.000). Therefore, this study comes to the conclusion that if small enterprises wish to be competitive in the global market, they should prioritize investing in market competitiveness and technology adoption. The study also suggests that small businesses prioritize technology adoption and market completeness in order to boost operational efficiency.