This article explores how advancements in 3D technologies, particularly in digitization and virtual restoration, present opportunities to better intervention strategies in cultural heritage. The research centers on cleaning procedures (a contentious aspect of restoration) utilizing virtual models as a supporting tool to evaluate different potential outcomes and aid decision making before intervention on the actual artifact. Once the virtual restoration testing is complete, a trial of cleaning systems aligned with the artifact's characteristics is conducted using buffered aqueous solutions and binary combinations of organic solvents as a method for identifying the most suitable. The conclusions (re)affirm the feasibility and effectiveness of employing 3D digital techniques in conservation and restoration practices, as they contribute to the decision making process in contentious procedures. This methodology ensures precision, safety, and rigor in cleaning processes. While this research primarily focuses on collections with didactic anatomical artifacts, it holds the potential for adaptation to other types of objects and cultural assets.