Drawing inspiration from the five levels of preventive medicine, this chapter presents a novel framework designed to comprehensively address academic misconduct and promote a culture of academic integrity within the higher education classroom. This framework moves beyond a reactive approach to misconduct, instead advocating for a proactive and holistic strategy that tackles the root causes of misconduct while implementing effective interventions. The first tier of this preventative model, primordial prevention, emphasises critically examining systemic factors that might contribute to misconduct, such as the academy’s traditional focus on the individual over the community or achievement over learning, and subsequently encourages systemic reform to create an environment that fosters academic integrity. Primary prevention focuses on cultivating a culture of integrity in the classroom, promoting ethical conduct through open communication, building relationships and raising awareness of and promoting responsible scholarship. Secondary prevention involves identifying and addressing potential risks for misconduct before it occurs and subsequently developing curricular and or pedagogical approaches to mitigate this risk. Tertiary prevention focuses on restorative practices, recognising that misconduct may occur despite preventative measures. This tier prioritises addressing violations in a manner that promotes student learning and reintegration into the academic community. When misconduct occurs, the focus is shifted away from punishment towards offering support and encouraging students to reflect on their actions and develop strategies to maintain academic integrity in the future. Finally, quaternary prevention would act to ensure that implemented measures of prevention, at any level, are unbiased and not inadvertently causing harm. Through the cyclical review and refinement of policies and practices related to the promotion of academic integrity, institutions can ensure that their efforts to promote academic integrity remain relevant, effective, and ethically sound. By integrating these five tiers, institutions can reduce the burden of misconduct on all stakeholders, promote student engagement, and ultimately enhance learning outcomes.