Solid organ transplantation is increasing worldwide. The number of surviving solid organ transplant recipients exceeds the capacity of transplant centers to solely care for them. While a transplant specialist has a necessary role in the care of solid organ transplant recipients, primary care providers also need to be well-versed in the evaluation and management of these patients. This chapter discusses the prevalence of solid organ transplantation, reviews the pre-transplant workup a solid organ transplant recipient is likely to have received, and provides a framework for the initial history-taking elements required for management of solid organ transplant recipients in the primary care setting.