The study aimed to explore how communication can influence young individuals to become blood donors. It sought to answer a key question: how do communication strategies impact the recruitment of donors within this age group? The research was structured around four primary objectives. First, it evaluated young people’s knowledge about blood donation through a content analysis of 14 campaigns. Second, it examined the communication strategies implemented by the Portuguese Institute of Blood and Transplantation (IPST) via an exploratory interview with an expert from the organization. Third, it investigated the motivations and barriers affecting young people’s willingness to donate, using a survey conducted with 390 participants, which revealed that more than half of respondents were not blood donors. Finally, it identified the most effective communication strategies and actions to promote blood donation. The findings suggest that future campaigns should prioritize precise segmentation based on behavioral criteria and adopt integrated marketing communication more broadly. This approach is expected to enhance the effectiveness of initiatives aimed at increasing donor recruitment among young people.