Virtual Reality (VR) is an established tool for cognitive and motor rehabilitation, with increasing adoption in clinical settings, offering immersive and engaging environments tailored to patients’ needs. This paper presents TaMelis Rehab, a VR-based rehabilitation system designed as a virtual home, where each room hosts a serious game targeting specific neurological impairments. The kitchen supports neglect rehabilitation through spatial attention exercises, the bathroom addresses apraxia with functional movement training, the living room aids aphasia recovery with language-based interactions, and the bedroom provides both diagnostic and rehabilitative applications for Parkinson’s patients. By simulating familiar environments, TaMelis Rehab enhances patient engagement and promotes the transfer of acquired skills to real-world scenario. This work presents the conceptual design of TaMelis Rehab, positioning it within the state of the art in VR rehabilitation, and discussing the methodological implications of future experimental validation. The proposed approach demonstrates how VR can create personalized, motivating, and effective rehabilitation experiences, bridging the gap between traditional therapy and innovative digital interventions.