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The electrochemical sensor has gained significant attention in biosensor design recently, thanks to its advantages like high sensitivity, affordability, and practicality. Although most disposable biosensors can prevent samples contamination, they cannot perform downstream analysis. In addition, increasing the usage of electrochemical sensors is beneficial for reducing costs, making it essential to develop a reusable electrode surface. In this study, the authors employed a glassy carbon electrode (GCE) modified with β-cyclodextrin (β-CD) through electro-grafting and solid-phase synthesis. The β-CD selectively recognizes the benzimidazole (BM) derivative via host-guest interactions. Since BM is a pH-responsive molecule, it can be released from the electrode surface in an acidic environment. This process allows the electrode surface to regenerate and be prepared for subsequent detections. During fabrication, the authors evaluated the conditions and performance of two modified electrodes (GCEβ-CD and GCEβ-CD/PEG-Me). Following this, the primary analyte (Mannose-BM) will be used to assess electrochemical detection and reusability in an acidic solution.

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Fabrication of Reusable Electrochemical Platform Based on the Host-Guest Interaction

  • 会议论文

  • 发表日期：

    2025年

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  • Zhi Jia Chen,
  • Wun Liang,
  • Muhammad Aneeq u Rehman,
  • Chian-Hui Lai

摘要

The electrochemical sensor has gained significant attention in biosensor design recently, thanks to its advantages like high sensitivity, affordability, and practicality. Although most disposable biosensors can prevent samples contamination, they cannot perform downstream analysis. In addition, increasing the usage of electrochemical sensors is beneficial for reducing costs, making it essential to develop a reusable electrode surface. In this study, the authors employed a glassy carbon electrode (GCE) modified with β-cyclodextrin (β-CD) through electro-grafting and solid-phase synthesis. The β-CD selectively recognizes the benzimidazole (BM) derivative via host-guest interactions. Since BM is a pH-responsive molecule, it can be released from the electrode surface in an acidic environment. This process allows the electrode surface to regenerate and be prepared for subsequent detections. During fabrication, the authors evaluated the conditions and performance of two modified electrodes (GCEβ-CD and GCEβ-CD/PEG-Me). Following this, the primary analyte (Mannose-BM) will be used to assess electrochemical detection and reusability in an acidic solution.