Nonviral Infections of the liver include bacterial, mycobacterial, fungal, and parasitic involvement of the liver parenchyma. The liver’s dual blood supply renders it uniquely susceptible to nonviral infections. Hepatic infections can present with a variety of clinical presentations that include asymptomatic hepatic enzyme elevation, symptomatic hepatitis, liver failure, scarring, and space-occupying lesions. Various bacteria can infect the liver. Gut bacteria, especially aerobic Gram-negative bacilli, such as Escherichia coli or Klebsiella pneumoniae, are the most frequent culprits of hepatic infections. The liver can also be involved in infections with Mycobacterium tuberculosis, Treponema pallidum, actinomycosis, and several other bacteria. Parasitic liver infections, which are influenced by hygiene and sanitation practices, vary in prevalence worldwide. Fungal infections of the liver typically occur in immunocompromised individuals and often present with disseminated patterns. Common fungal infections include those caused by Candida, Cryptococcus, and Histoplasma. Biliary parasites can cause symptoms of biliary obstruction, cholecystitis, and cholangitis. Diagnosing these infections requires a high index of suspicion and consideration of endemic patterns in specific regions. This chapter describes the involvement of the liver by various nonviral infections.