Inflammatory dermatological disorders are common in every part of the world. The conditions are seen in all age groups. Some conditions are mild and hardly require treatment in patients where the condition is at the lower extreme of even the mild condition—an example is miliaria (prickly heat, heat rash) in which people whose experience of this relatively mild inflammatory condition is very mild considering the overall mild spectrum. On the other hand, some inflammatory skin disorders are dermatological emergencies with systemic associations that make them potentially deadly—and they are known to cause deaths like toxic epidermal necrolysis. The patient with this condition should at least suspect this skin condition to be very severe and seek medical help at the right place immediately as delay could be catastrophic; and when any doctor in a public hospital or private medical facility encounters a patient with this condition, there should be no prevarication (even when the doctor knows that they cannot single-handedly manage the condition)—rather, the general practitioner should provide just the emergency attention and refer to a center with appropriate specialists (unless they have the equipment but not the manpower, in which case they should invite the specialists to immediately come and institute the correct line of management and direct the overall management). It is because of this wide range of presentation of inflammatory conditions that this chapter is one of the longest in the book, covering more dermatological topics than the others. The chapter starts with the common or mild conditions of which miliaria is a prototype and ends with erythroderma, toxic epidermal necrolysis, and fixed drug eruptions. The list of the topics in this chapter is as follows: miliaria, acne vulgaris, severe and complicated acne vulgaris, acne keloidalis nuchae, urticaria, acute urticaria, recurring acute urticaria, papular urticaria, lichen simplex chronicus, allergic contact dermatitis, chronic chemical irritant contact dermatitis, skin bleaching, segmental vitiligo, disseminated lenticular leukoderma (idiopathic guttate hypomelanosis), erythroderma, toxic epidermal necrolysis (TEN), and fixed drug eruptions.