Humankind is witnessing a rapid progress toward multifunctional materialsMultifunctional materials endowed with multimodal control of their propertiesProperties. In particular, biomaterialsBiomaterials are increasingly providing solutions to complex challenges in the nanomedicineNanomedicine field, from the compartmentalizationCompartmentalization and deliveryDelivery of unstable moleculesUnstable molecules or even theIn situ synthesis in situ synthesisSynthesis of biologicalBiological active moleculesMolecule toBiological active molecules the synergistic theranostic strategiesSynergistic theranostic strategies that join therapyTherapy and diagnosisDiagnosis in a single system. Hence, considering the complementary of different materialsMaterial, we intend to provide in this chapter a discussion on the most recent and relevant progress in biomaterialsBiomaterials for therapeutic applicationsTherapeutic Applications, starting from hydrogelsHydrogel and liposomesLiposomes to the combination of these materialsMaterial with compositesComposite toward smart multifunctional materialsMultifunctional materials.