Building on a prior discussion of medicinal chemistry and the role of small molecules, this chapter focuses on praziquantel. Its chemical classification as a tetrahydroisoquinoline is detailed, alongside an analysis of key molecular descriptors and physicochemical properties. Additionally, the industrial-scale synthesis of praziquantel and its characterization are examined in the context of its development as a drug product. These insights provide a comprehensive overview of praziquantel’s attributes and its relevance in medicinal chemistry.

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From Small Molecule to Drug Product: The Chemical Journey of Praziquantel

  • David Maillard,
  • Thomas Spangenberg,
  • Yara Sylla

摘要

Building on a prior discussion of medicinal chemistry and the role of small molecules, this chapter focuses on praziquantel. Its chemical classification as a tetrahydroisoquinoline is detailed, alongside an analysis of key molecular descriptors and physicochemical properties. Additionally, the industrial-scale synthesis of praziquantel and its characterization are examined in the context of its development as a drug product. These insights provide a comprehensive overview of praziquantel’s attributes and its relevance in medicinal chemistry.