The previous chapter introduced various techniques to reduce the amount of data transmission and, hence, the power consumption in edge sensing applications. Performing processing in the digital domain can lead to a significant data reduction, at the cost of a higher power consumption of the digital circuits. As an alternative, event-driven level-crossing ADCs can be used. Such ADCs exploit the properties of signals such as the electrocardiogram or action potentials by only sampling once these signals show activity. This chapter will explore the use of level-crossing ADCs for biomedical applications and will provide an in-depth comparison of such ADCs with standard Nyquist-rate ADCs.