In recent years, cultural routes have become instruments of intercultural knowledge and discovery. For this reason, it has become indispensable to guarantee access to them for all citizens, regardless of physical, cultural, social, economic or other conditions that might limit their enjoyment. The demand for ‘tailor-made’ cultural products designed to meet specific psychological, physical and recreational needs is profoundly changing supply systems in the sector, enhancing the economic and social value of local communities and playing a fundamental role in building the sustainable and accessible world of the future. This requires the creation of a culture of sustainability that strategically links all parties involved in the development of itineraries in accordance with planning criteria and tools that contribute to the co-creation of an equitable and sustainable system. The chapters in this book explore the conditions and factors that enable itinerary tourism to be socially and economically beneficial for local communities, with a view to a radical paradigm shift in the perception of inclusiveness, linked to a new ethics of heritage conservation and use.