Waste management has become a global concern as the total amount of waste generated is overwhelming, including municipal, industrial, and hazardous waste, which all contribute to the problem. Waste streams get contaminated with hazardous materials, making recycling more challenging. Encouraging individuals and businesses to reduce, reuse, and recycle and its management is challenging. To manage biomedical waste, there is a need for cost-effective, eco-friendly, and less contaminating approaches for a greener and safer environment. The eco-friendly handling of waste includes the 3Rs, composting organic waste, waste-to-energy technologies, and zero-waste system to eliminate waste. The last portion of the chapter is the conversation of waste into goods with additional values like the use of waste to produce bioactive compounds like carotenoids and the conversation of food waste to carbon dots contributing to the concept of circular economy. Feedstocks from dairy industry are used for the generation of biofuels like bioethanol and biogas. Pyrolysis is a microbial technology used for the formation of bio-oil and biochar. Bioenergy production utilizing biowaste can open new avenues in the field of waste valorization and energy research. Overall, the chapter aims to provide an overview of current challenges, eco-friendly waste handling, and conversion of waste into goods with additional values. By implementing these strategies and promoting public awareness, we can have more sustainable waste management practices that benefit both the environment and society.