Subtractive manufacturing encompasses a broad range of techniques where material is removed from a solid block to form a desired shape. This includes conventional processes such as turning, drilling, and milling, as well as abrasive-based and other non-traditional machining techniques. This chapter focuses on the influence of material properties on machinability, with particular emphasis on chip-removal processes for metallic alloys. It examines how microstructure and mechanical properties of the material impact machining performance, including tool wear mechanisms and methods for its reduction. The discussion is then extended to abrasive and selected non-traditional processes, considering how material-specific factors influence their effectiveness.