The development and progress of human society hinges on our ability to continuously develop knowledge, skills and different technologies with which we explore and effectively use natural resources. Technology has and continues to transform every aspect of our lives. Our economies are technologically driven as are our social and health systems. Education as a driver of development and societal participation has been equally transformed by technology. This chapter is about teaching and learning chemistry with available and applicable technologies. Available technologies with potential use in chemistry classrooms are explored and discussed, as well as how chemistry teachers can exploit such technologies, integrate and use them in teaching. The chapter also presents feasible actions teachers can take to develop their knowledge for teaching with technology (namely, the Teacher's Technological Pedagogical Content Knowledge).