This study explores the transformative potential of disruptive digital marketing technologies in empowering small and medium-sized enterprises (SMEs) within the African healthcare sector. A systematic literature review identifies key factors influencing adoption, challenges, and benefits. The findings indicate that digital marketing enhances operational efficiency, strengthens customer engagement, and improves sustainability. However, SMEs face barriers such as financial constraints, limited technological access, and digital literacy gaps. The study highlights the critical role of digital literacy and organisational culture in facilitating digital transformation. It also emphasises the need for policymakers to implement targeted interventions, including training programmes and resource accessibility, to foster a digital-friendly ecosystem for healthcare SMEs. Practical implications include strategies for SME managers and healthcare professionals to enhance market reach and innovation. The study contributes to the theoretical discourse on digital marketing adoption in emerging economies and offers insights for future research on the long-term impact of digital strategies in healthcare.