Sprouting angiogenesis is the most representative process of tumor angiogenesis. It is featured as the formation of new vascular branches from blood vessels towards tumor. These new vascular branches are made to supply the necessary nutrients for the further growth of existing tumor tissue. The entire process of angiogenesis is highly complex. It involves production and utilization of biomolecules, transition between subtypes of endothelial cells. In addition, it incorporates cell interaction, division and migration. In order to understand the mechanism of sprouting angiogenesis, microfluidic cell culture platform has been used in combination with human induced pluripotent stem cell derived endothelial cells (iPSC-ECs) to form a physiological relevant micro-environment. In this paper, we explore the possibility of using bio-modeling technique to model sprouting angiogenesis in microfluidic cell culture platform and to conduct in silico experiment. We utilize Petri nets for modeling the cell transition and associated constraints. The environmental and spacial factors are realized using custom 2-dimensional grids. The model is able to capture the essence of endothelial cell transition and migration in sprouting angiogenesis using this abstract computational solution.