Diastasis of rectus abdominis muscle (DRAM) has been long neglected by general surgeons because it has not been associated with symptoms or complications. Recently, this reality has undergone several changes. First, understanding that DRAM has a significant impact on the risk of recurrence in abdominal hernia repairs as well as comprehending the functions of the abdominal wall far beyond just containing the abdominal organs. In addition, the recent description of numerous minimally invasive, laparoscopic or robotic, techniques for repairing DRAM with or without abdominal hernias. The main indication for Endoscopic Onlay Repair (ENDOR) is for patients with midline abdominal hernia associated with symptomatic diastasis of the rectus abdominis muscle without excess skin/subcutaneous tissue. Patients presenting with isolated DRAM are also good candidates; however, it is important that the patient’s expectation, which is generally aesthetic, is understood. Simple plication of the DRAM does not return the tapered shape (silhouette) of the abdomen, which can be achieved through conventional abdominoplasty, where lateral plications can be performed and/or liposuction is associated. Absolute contraindications do not differ from those of the other minimally invasive procedures: patients not candidates for general anesthesia and patients with coagulopathies. Although it is not yet established in the literature, the situations that we understand as relative contraindications are as follows: