This chapter showcases the sociopolitical factors embedded in the mental health challenges, particularly in Asian regions, and how the heterogeneity of the marginalized populations in this region could enrich the future development of Indigenous psychology at the global level, through a reflexive and systemic analysis from the authors of the challenges and resilience among the political minorities. We first highlight the importance of why addressing minority groups in the Indigenous psychology discipline is the critical link to deconstruct the power and political agenda embedded in the mainstream society narratives, especially within psychology discipline. Then we address the self-colonizing agenda in psychology through critical reflexivity on the challenges of mental health among two key vulnerable populations in Asia regions (Temiar tribe in Malaysia and migrant domestic workers from Indonesia and Philippines). Lastly, we propose decolonizing blueprints for the Indigenous psychology discipline through inclusiveness of cultural-political minorities in our research and practices to bridge the gaps of WEIRD psychology and global psychology.