Potential continuation or acceleration of climate change could increase the risk of critical bridge components or systems’ failure. This study investigates the impact of extreme climate loads, such as temperatures, on the safety and serviceability of a continuous slab-on-girder bridge. A three-span continuous slab-on-girder bridge designed according to the Canadian Highway Bridge Design Code was simulated by a 3D nonlinear finite element model. The bridge is investigated for the effect of different levels of temperatures combined with other gravity loads. The initial results show that the load over capacity ratio increases and exceeds 1.0 when the damage affects negative moment zones (over the interior supports). This may lead to a change in bridge classifications (from class 1 or 2 to class 4) causing the bridge to collapse. Further research is required to investigate the safety of the bridge elements, connections, and integrity of the bridge system while satisfying CSA-S6-19 design and evaluation requirements.