This work pays tribute to the work of Professor Magnani by analyzing and applying his Eco-Cognitive Abduction Model (also known as the EC-Model) to introduce axiological values’ role in the generation of scientific hypotheses. For this purpose, the cognitive dimension of the researcher is proposed in this work as a complementary factor to better understand the scientific paradigm shift. In particular, it is assumed that the experience of discovering a surprising fact that neither current theories nor methodologies can account for generates a state of radical ignorance that can provoke in the agent the emotion of anguish in the face of the imperative need to find a solution. Faced with ignorance as the only available evidence of the fact that triggers anguish, the agent’s abducted hypotheses will be much more fragile than usual because they contain very distant elements, which will imply a more significant commitment to the interpretation of the scientific discipline involved, as well as to the agent’s own vision of how the paradigm should be understood. This fragility, however, does not undermine the process but revitalizes the discipline in crisis with novel proposals that motivate suggestive new lines of investigation.