Prematurity is defined as birth prior to 37 weeks gestation, classified further by level of prematurity (late, moderate, very, or extremely) and by birth weight (low, very low, and extremely low). Preterm infants are at risk for serious respiratory, cardiovascular, intestinal, neurological, and infectious complications, which have short- and long-term sequelae that impact morbidity and mortality. An interdisciplinary approach to managing complications is essential in supporting families and caregivers with a premature infant.