Transnational organized crime poses a significant and growing threat to national and global security affecting public safety, human security, economic and governmental stability. As reported in GITOC [15, p. iii], ‘a conservative estimate of the value of organized crime was $3.6–$4.8 trillion, in 2015/2016, 7% of global GDP. The broader impact of organized crime is difficult to assess as it is multi-dimensional, and shared across the private, public sector, and society itself’. According to Saha and Chakrabarti [44, p. 112] non-traditional security is characterized by threats to national and global security that transcend traditional thinking in terms of military and non-state actors. Nontraditional security requires the global and national community to consider the new challenges, such as ‘…epidemiological diseases, human rights violation, terrorism, illegal migration, climate change, cyberterrorism/crime and the like’. What is therefore required is a new way to see the world: a complexity worldview that sees the world as interconnected and interdependent. This chapter examines the influence of transnational organized crime on nontraditional security through a complexity-informed inquiry. In particular, a network analysis (mapping) has been conducted to illustrate the direct and indirect influence of transnational organized crime on nontraditional security, further exploring the effects on global and public health security.