Antibiotic stewardship is a critical component of orthopedic surgery, aimed at optimizing the use of antimicrobial agents to enhance patient outcomes and combat the rising threat of antimicrobial resistance. This abstract highlights the importance of judicious antibiotic utilization in orthopedic procedures, emphasizing the need for tailored prophylactic regimens based on surgical site infection risk assessments and local resistance patterns. Evidence-based guidelines and multidisciplinary collaboration are pivotal in achieving successful antibiotic stewardship, minimizing adverse effects, and curbing the emergence of drug-resistant pathogens. By prioritizing the rational use of antibiotics in orthopedic surgery, we can improve patient care while safeguarding the efficacy of these vital therapeutic agents.