Using the theory of path dependence, this chapter increases our understanding of the hyper-stability of certain practices in healthcare as well as of the whole health system. Technological, institutional, and organizational path dependences are based on self-reinforcing mechanisms that create such stability, making deviations from existing paths extremely difficult. If coordination and complementarity or learning and adaptive expectation effects are at work, transformation toward more integrated care will be difficult, if not impossible. Policy-makers, health professionals, and healthcare managers should be aware of these difficulties when aiming for technological, institutional, or organizational change.