Interoperability plays a crucial role in enabling integrated care by facilitating seamless information exchange among healthcare stakeholders. This chapter explores the significance of interoperability in healthcare, emphasizing its potential to improve care coordination, patient outcomes, and foster innovation. It examines the evolution from Electronic Medical Records to more comprehensive Electronic Health Records, highlighting the challenges in achieving true semantic interoperability. The chapter discusses various technical, legal, and organizational barriers to interoperability, including data standardization issues, privacy concerns, and cultural resistance. It presents strategies to overcome these challenges, such as adopting standardized frameworks, implementing robust data governance, promoting collaboration among stakeholders, and investing in technical infrastructure. The importance of native interoperability is emphasized, along with the need for supportive policies and regulations. Addressing these aspects can drive healthcare systems toward more effective, person-centered integrated care, ultimately improving health outcomes and system efficiency. The chapter concludes that while significant progress has been made, achieving comprehensive interoperability remains an ongoing challenge requiring concerted efforts from all healthcare stakeholders.