Antibiotics as well as antiseptics and disinfectants that affect the bacterial cell membrane and other structural targets are discussed. Background biochemistry information on lipids and membranes is provided. The antibiotics include gramicidin, tyrocidin, polymyxin, daptomycin, bacteriocins, lantibiotics, triclosan, isoniazid, magainin, and defensin. Inhibitors targeting the cell division protein, FtsZ, are also included. Mechanisms of action of the antibiotics and resistance development against the antibiotics are discussed.