Introduction to Antibiotics
摘要
This chapter is an introduction to antibiotics. Topics discussed are definition of antibiotics, characteristics of an ideal antibiotic, history of antibiotics, and discovery of the first antibiotics, penicillin, gramicidine, streptomycin, chloramphenicol, tetracycline etc. Background biochemistry information needed for understanding mechanisms of action of antibiotics is briefly presented including discussions on enzymes, inhibitors, and thermodynamics of metabolic pathways.