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Pharmacovigilance is essential for protecting public health as it identifies and evaluates adverse events (AEs) associated with the use of pharmaceuticals and vaccines. This study explores a novel approach for detecting adverse drug reactions which integrates AE ontology into a zero-inflated negative binomial model. Correlated AEs are more effectively disentangled by taking account of their similarities while accounting for excess of zero counts. The aim of this contribution is to numerically assess the model on Italian pharmacovigilance data.

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Exploring Ontology-Based Mining of ADRs

  • 会议论文

  • 发表日期：

    2025年

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  • Kenenisa Tadesse Dame,
  • Pietro Belloni,
  • Ugo Moretti,
  • Fabio Scapini,
  • Marco Tuccori,
  • Alessandra R. Brazzale

摘要

Pharmacovigilance is essential for protecting public health as it identifies and evaluates adverse events (AEs) associated with the use of pharmaceuticals and vaccines. This study explores a novel approach for detecting adverse drug reactions which integrates AE ontology into a zero-inflated negative binomial model. Correlated AEs are more effectively disentangled by taking account of their similarities while accounting for excess of zero counts. The aim of this contribution is to numerically assess the model on Italian pharmacovigilance data.