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Acute gout is the inflammatory reaction provoked by monosodium urate (MSU) crystals when they form within a joint. Hyperuricemia is necessary for MSU crystal formation. Gout affects mainly males, due to their physiologically higher serum uric acid (UA) levels, and there is epidemiological evidence that the prevalence of gout and hyperuricemia is on the increase in western and Asian populations in both sexes and with aging. Here we describe the pathophysiology of gout, its metabolic alterations, and therapeutic options.

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Gout

  • 章节

  • 发表日期：

    2026年

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  • Sonia Nasi,
  • Alexander So

摘要

Acute gout is the inflammatory reaction provoked by monosodium urate (MSU) crystals when they form within a joint. Hyperuricemia is necessary for MSU crystal formation. Gout affects mainly males, due to their physiologically higher serum uric acid (UA) levels, and there is epidemiological evidence that the prevalence of gout and hyperuricemia is on the increase in western and Asian populations in both sexes and with aging. Here we describe the pathophysiology of gout, its metabolic alterations, and therapeutic options.