Various reproductive events, especially pregnancy and childbirth, affect the course of bipolar disorder. Women are at a particularly high risk of recurrence of mood episodes with or without psychotic features after delivery. Despite its association with maternal suicide, infanticide, and psychiatric hospitalization, there is a lack of research on the management of bipolar disorder during and after pregnancy. Both sleep loss and insomnia are common during and after pregnancy and can adversely affect the course of bipolar disorder. To date, research has focused primarily on the role of sleep disruption in postpartum psychosis in women with bipolar I disorder. Emerging research shows that sleep-promoting atypical antipsychotics are effective in the prevention and acute treatment of bipolar mood episodes in the postpartum period. Future research should focus on the effect of sleep loss/insomnia in women with bipolar II and other specified bipolar and related disorders. In addition, understanding the impact of sleep loss on bipolar postpartum depression and its comorbidities is necessary because anxiety and mixed features are common in the postpartum period and may increase the risk of self-harm.