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Innovative LIVE biomarkers are essentially needed for the diseases of the neurodegenerative dementias, Parkinson’s and the epilepsies since these diseases may correlate with the archetypal neurodegenerative disease of dementia, Alzheimer’s. We have become acutely aware that,these biomarkers for diseases of dementias seem to be ubiquitous in brain sites without distinction …tau peptides, beta amyloids, and Lewy bodies are found in all three diseases. (Mayo Clinic-Alzheimer’s disease. Symptoms and Causes. Mayo Clinic. 2020. Amyloidosis describes the twisted pathological turns that take place during naturally occurring physiological events in the brain, body and even the skin of patients who present with neurodegeneration. Therefore, the present chapter discusses a next generation “uptick” nanotechnology that demonstrates a unique, real time imaging inventive art enabling a different kind of look at the neuroanatomical sites such as the brain, actually, to see inside neuronal circuitry at the nanoscale. Neuromolecular imaging of the tau peptide LIVE in the brain of the neurodegenerative dementias, Parkinson’s and the epilepsies is presented using a quantum sensing nanotechnology to discern the temporal and spatially sensitive voltaic image of the polymeric tau metal complex, which is video-tracked by the BRODERICK PROBE® nanoprobe online and in real time. Tau is imaged LIVE in dorsal striatum of the living Parkinson’s animal as well as within the anterior temporal neocortex of the epilepsy patient, intraoperatively, with NYU Institutional Review Board (IRB) approval. The Broderick nanoprobe capacitates redox matching of the metallopolymer of the tau peptide, LIVE, inferably at one of the oxidation states of the transition metal polymeric compounds of cobalt to further polymerize with the phosphorylated Broderick nanoprobe. Studies of the striking consequences among intensities of phosphorylated tau are quantified. An operationally stable voltaic image of the soluble healthy tau Metallopolymer at an electrochemically positive waveform is reported. Imaging tau on line along with tau quantification, made possible in the living, functional animal and human being, is relevant to both individual and societal longevity, and this relevance is inexorably critical to and on behalf of humanity.

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Neuromolecular Imaging Tau in Amyloidosis with Quantum Polymer Sensors in Parkinson’s and in the Epilepsies

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  • 发表日期：

    2025年

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  • Patricia A. Broderick

摘要

Innovative LIVE biomarkers are essentially needed for the diseases of the neurodegenerative dementias, Parkinson’s and the epilepsies since these diseases may correlate with the archetypal neurodegenerative disease of dementia, Alzheimer’s. We have become acutely aware that,these biomarkers for diseases of dementias seem to be ubiquitous in brain sites without distinction …tau peptides, beta amyloids, and Lewy bodies are found in all three diseases. (Mayo Clinic-Alzheimer’s disease. Symptoms and Causes. Mayo Clinic. 2020. Amyloidosis describes the twisted pathological turns that take place during naturally occurring physiological events in the brain, body and even the skin of patients who present with neurodegeneration. Therefore, the present chapter discusses a next generation “uptick” nanotechnology that demonstrates a unique, real time imaging inventive art enabling a different kind of look at the neuroanatomical sites such as the brain, actually, to see inside neuronal circuitry at the nanoscale. Neuromolecular imaging of the tau peptide LIVE in the brain of the neurodegenerative dementias, Parkinson’s and the epilepsies is presented using a quantum sensing nanotechnology to discern the temporal and spatially sensitive voltaic image of the polymeric tau metal complex, which is video-tracked by the BRODERICK PROBE® nanoprobe online and in real time. Tau is imaged LIVE in dorsal striatum of the living Parkinson’s animal as well as within the anterior temporal neocortex of the epilepsy patient, intraoperatively, with NYU Institutional Review Board (IRB) approval. The Broderick nanoprobe capacitates redox matching of the metallopolymer of the tau peptide, LIVE, inferably at one of the oxidation states of the transition metal polymeric compounds of cobalt to further polymerize with the phosphorylated Broderick nanoprobe. Studies of the striking consequences among intensities of phosphorylated tau are quantified. An operationally stable voltaic image of the soluble healthy tau Metallopolymer at an electrochemically positive waveform is reported. Imaging tau on line along with tau quantification, made possible in the living, functional animal and human being, is relevant to both individual and societal longevity, and this relevance is inexorably critical to and on behalf of humanity.