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Natural compounds are being explored as a promising strategy for treating neurodegenerative disorders. This study describes natural cannabinoids from Cannabis sativa, including (−)-cannabidiol (CBD) analogues with therapeutic potential. The underlying molecular mechanisms of CBD as a therapeutic candidate for epilepsy, Alzheimer’s disease (AD), and Parkinson’s disease (PD) were comprehensively clarified. CBD acts as an endogenous agonist for cannabinoid receptors, indirectly suppressing glutamate release and stimulating cannabinoid receptor 1 and 2 receptors. This mechanism makes CBD effective in treating epilepsy and PD while promoting neuroprotection through various signal transduction pathways. CBD also shows promise as a therapeutic candidate for AD by preventing glycogen synthase kinase 3β hyperphosphorylation induced by β-amyloid. Furthermore, this chapter incorporates brain imaging evidence related to CBD exposure in both healthy subjects and patients at a clinical high risk (CHR) for psychosis. By examining the impact of CBD on human brain function through neuroimaging studies, this chapter aims to provide a mechanistic understanding of CBD’s potential role as a therapeutic strategy with a neuroprotective effect.

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Potential Therapeutic Strategy for Neurodegenerative Disorders: Insights from Natural Cannabis Compounds and Analogues

  • 章节

  • 发表日期：

    2025年

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  • Lei Tian,
  • Bingxing Zhang,
  • Xiuding Yang,
  • Xiaopei Zhai,
  • Yue Gao,
  • Yunfei Zhang,
  • Xiaolin Xie,
  • Dezhu Zhang,
  • Chengyuan Liang

摘要

Natural compounds are being explored as a promising strategy for treating neurodegenerative disorders. This study describes natural cannabinoids from Cannabis sativa, including (−)-cannabidiol (CBD) analogues with therapeutic potential. The underlying molecular mechanisms of CBD as a therapeutic candidate for epilepsy, Alzheimer’s disease (AD), and Parkinson’s disease (PD) were comprehensively clarified. CBD acts as an endogenous agonist for cannabinoid receptors, indirectly suppressing glutamate release and stimulating cannabinoid receptor 1 and 2 receptors. This mechanism makes CBD effective in treating epilepsy and PD while promoting neuroprotection through various signal transduction pathways. CBD also shows promise as a therapeutic candidate for AD by preventing glycogen synthase kinase 3β hyperphosphorylation induced by β-amyloid. Furthermore, this chapter incorporates brain imaging evidence related to CBD exposure in both healthy subjects and patients at a clinical high risk (CHR) for psychosis. By examining the impact of CBD on human brain function through neuroimaging studies, this chapter aims to provide a mechanistic understanding of CBD’s potential role as a therapeutic strategy with a neuroprotective effect.