The Longevity Economy represents a seismic paradigm shift in how humanity approaches aging, health, and our very notion of “life”. Whereas traditional healthcare focuses on treating conditions once they appear, this emerging model envisions lifelong Amplified Intelligence, continuous neuroplasticity, and an exponential synergy between our biological neural networks and advanced digital systems. Grounded in Affectoneuroimmunology (ANI) and Informational Medicine, the Longevity Economy is driven by the principle that all aspects of biology, medicine, and social dynamics are ultimately reducible to signals, data streams that can be measured, modeled, and amplified. Drawing on real-time biomarkers, AI algorithms, and personalized molecular and behavioral strategies, this paradigm aims not only to extend lifespan but also to expand healthspan—the period during which individuals enjoy peak physical, cognitive, and emotional vitality. I contend that the ultimate ‘longevity drug’ will not be a single molecule but rather an adaptive algorithm, with future clinics increasingly relying on perpetually learning AI systems alongside, or even in place of, traditional human doctors. As data and life sciences converge, the traditional boundaries between the digital and physical realms will dissolve, unveiling a profound and exponential pathway for human progress.