We have already discussed the performance, success, and failures of SCs. Now, it is time to discuss approaches for creating such a network. In particular, it is necessary to clarify important decisions that must be made in order to set up an SC. Such a network setup comprises both decisions about the usage and installation of network nodes (represented by factories and/or warehouses or any other immobile equipment such as supply regions or markets) as well as transportation links connecting different network nodes to enable the flow of materials as well as information between these nodes. In order to set up a supply network, we have to cope with the challenge that long-lasting SC design (SCD) decisions (with several years of validity) have to be coordinated with mid-term network configuration decisions (commitments for some weeks or months) as well as with operational deployment decisions.