Today, 70% of the world’s malnourished live in conflict and humanitarian settings. While malnutrition impacts entire emergency-afflicted populations, women, adolescent girls, and children are at much greater risk of experiencing nutrition-related morbidity and mortality. Undernutrition specifically underlies 45% of all deaths among children under 5 years globally. Children under 5 years from 15 countries experiencing humanitarian emergencies account for about 65% of the world’s acutely malnourished or wasted children (30 million children). Furthermore, children in humanitarian settings account for 75% of the world’s chronically malnourished or stunted children. For women and girls, the data reveal a similar story. Almost seven million pregnant and lactating women and girls in humanitarian settings are acutely malnourished with anemia rates among girls and women of up to 60%. To address the burden of malnutrition, nutrition-sensitive, nutrition-specific, and multi-sectoral interventions have been developed, tailored, and implemented. However, many challenges and barriers to implementation exist given the complexity of these settings and populations. To effectively improve malnutrition in conflict and humanitarian contexts, global stakeholders must commit to sustainable, coordinated, evidence-based, and data-driven actions.