Helminthic infections remain a major public health concern and contribute significantly to the disability-adjusted life years, especially among people living in the low- and middle-income countries of sub-Saharan Africa and South Asia. Periodic mass deworming with anthelminthics along with the water, sanitation, and hygiene (WASH) interventions remain the mainstay of helminthic control. However, concerns around potential anthelmintic resistance, existing mass deworming coverage, reinfections, and uptake and adherence to WASH interventions continue to pose challenges. This chapter discusses the evidence around anthelmintics and WASH interventions, alongside exploring the reasons for mixed findings and varying interpretations of the existing evidence.