Optimizing procedures for neuro-muscular rehabilitation involves a multidimensional approach that combines theoretical and clinical aspects from a broad spectrum of fields, favoring the development of innovative therapeutic strategies. A modern and effective way to combine entertainment with therapeutic exercises is Virtual Reality (VR) applications, which play an essential role in facilitating the locomotor rehabilitation process in an engaging and motivating way for patients. This paper proposes a combined solution of virtual reality and a serious game that can be useful in neuro-muscular rehabilitation therapeutic procedures at a patient’s home. It was designed as a soccer game where the patient has to hit a ball and strike a target, and exercise helps the patient recover the mobility of the lower limb. The software application was developed using the Unity 3D engine and subsequently deployed on a smartphone integrated into a virtual reality headset. Lower limb kinematics are captured by an MPU9250 inertial measurement unit (IMU) interfaced with an ESP-WROOM-32 development board. The ESP32 module, operating in WiFi mode, establishes a wireless communication channel with the smartphone application, enabling real-time data exchange and immersive VR interactions.