The augmentation of natural perception and volitive agency of humans through artificially intelligent technology necessitates a sober reflection. This applies above all to the use of Artificial Intelligence (AI) in the military domain. A transparent public discourse on such technologies needs to be conducted. With a view to the responsible use of artificially intelligent systems in future warfare, this chapter considers the interplay between science and technology and military requirements. Vice versa, understanding the potential of AI-based technologies will open up new operational options. Moreover, light is shed on legal and ethical considerations. A subjective assessment of the current security situation forms the starting point from which a military threat analysis emerges. A clarification of the role of AI in data and information fusion makes it clear why fusion engines need to accelerate the targeting cycle. Based on what is legally required and necessary for mission success, considerations of human-centric systems design form a central section. The Future Combat Air System serves as an example. Because military AI affects the way armed forces think and act, this chapter concludes with three recommendations. May it inspire a fruitful exchange between the different communities dealing with military operations and defense research.