As a practice framework, the GLM is applied differently to individual clients and populations depending on their setting and individual needs. Implementing the GLM with fidelity therefore is not nearly as simple as ensuring that everyone gets the same treatment experience. Designing interventions and putting them into practice requires several layers of consideration—including the core values, knowledge-related principles, and practice guidelines—to understanding how each client’s primary human goods were (and weren’t) implicated in their harmful behaviors. This chapter reviews the fundamentals of GLM design and offers ideas for implementation that include client culture, history of adversity, and specific risks and protective factors.