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For the rapidly progressing field of microfluidics, it is crucial to prioritize precision and efficiency. This paper introduces an innovative micromillingMicromilling technology for fabricating microfluidic devicesMicrofluidic device for Escherichia coli (E. coli) detection. E. coli is the most common bacteria found in urinary tract infections, which often causes women to suffer easily. The method effectively combines a glass substrate with polydimethylsiloxane (PDMSPolydimethylsiloxane (PDMS)) in order to construct intricate channels and structures within the device. By optimizing the micromillingMicromilling process, we have enhanced its precision and adaptability. Moreover, by utilizing PDMSPolydimethylsiloxane (PDMS)—an optically transparent and biocompatible elastomer—in conjunction with a robust glass substrate, our microfluidic system ensures both adaptability and stability. Three distinct designs of microfluidic devicesMicrofluidic device featuring different channel patterns and overall layouts were developed using computer-aided design software to ensure meticulous design and simulation accuracy. To simulate fluid flow, the COMSOL Multiphysics software was utilized. The fabrication process involved mixing a PDMSPolydimethylsiloxane (PDMS) base with a curing agent to create a uniform mixture. A thorough functionality test of each device is conducted by injecting liquid into the microchannels while checking for any possible leaks. The fluid's movement at the inlet is driven by both gravity due to its vertical orientation, and capillary forces acting upon it during experimentation. No leakage is observed in all the duplicates, but some are clogged.

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Biosensor-Based Microfluidic Chip Fabrication for the Treatment of Microbacteria in Women

  • 章节

  • 发表日期：

    2026年

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  • Liana Izzah Rosli,
  • Noor Hasmiza Harun,
  • Muhammad Rosli Adbullah,
  • Azimah Abdul Wahab,
  • Mohd Azerulazree Jamilan,
  • Dzun Noraini Jimat

摘要

For the rapidly progressing field of microfluidics, it is crucial to prioritize precision and efficiency. This paper introduces an innovative micromillingMicromilling technology for fabricating microfluidic devicesMicrofluidic device for Escherichia coli (E. coli) detection. E. coli is the most common bacteria found in urinary tract infections, which often causes women to suffer easily. The method effectively combines a glass substrate with polydimethylsiloxane (PDMSPolydimethylsiloxane (PDMS)) in order to construct intricate channels and structures within the device. By optimizing the micromillingMicromilling process, we have enhanced its precision and adaptability. Moreover, by utilizing PDMSPolydimethylsiloxane (PDMS)—an optically transparent and biocompatible elastomer—in conjunction with a robust glass substrate, our microfluidic system ensures both adaptability and stability. Three distinct designs of microfluidic devicesMicrofluidic device featuring different channel patterns and overall layouts were developed using computer-aided design software to ensure meticulous design and simulation accuracy. To simulate fluid flow, the COMSOL Multiphysics software was utilized. The fabrication process involved mixing a PDMSPolydimethylsiloxane (PDMS) base with a curing agent to create a uniform mixture. A thorough functionality test of each device is conducted by injecting liquid into the microchannels while checking for any possible leaks. The fluid's movement at the inlet is driven by both gravity due to its vertical orientation, and capillary forces acting upon it during experimentation. No leakage is observed in all the duplicates, but some are clogged.