This chapter delves into the use of cross-linking for the treatment of post-LASIK ectasia, a rare yet formidable complication following corneal laser surgery, representing the majority of secondary ectasias after refractive procedures. The section meticulously examines the shared morphological characteristics between progressive keratoconus and post-LASIK ectasia, underscoring the effective use of cross-linking (CXL) in the latter to arrest progression. Focusing on the standard “Dresden protocol,” the chapter scrutinizes the epithelium-off procedure’s role, employing riboflavin and UVA radiation to strengthen the corneal tissue and enhance its biomechanical integrity. Alternative techniques, including a combination of CXL with adjuvant refractive procedures, emerge as effective and safe options with optimized topographic and visual outcomes in post-LASIK ectasia. Additionally, the concomitant application of CXL and LASIK constitutes a prophylactic measure against ectasia, demonstrating early corneal stabilization and improved refractive outcomes. Despite potential complications such as infections and corneal haze, the comprehensive analysis of refractive outcomes underscores the safety and efficacy of CXL in post-LASIK ectasia treatment.