Marginal or peripheral sterile corneal infiltrates are localized, noninfectious inflammatory processes of the ocular surface that can be associated with several etiologies. There are reports of sterile corneal infiltrates after various refractive procedures. Local immune reactions and a mixture effect of the flap creation and laser ablation on the cornea, associated with other ocular surface and/or systemic factors, can trigger this complication. The patients typically have a sluggish onset of the clinical signs with mild to lack of symptoms because of the gradual evolution of the infiltrates. Usually, the condition presents from the first to the fifth day after the surgery; visual acuity is not severely affected, and the condition affects both eyes if operated on the same day. Although the exact mechanism of this complication remains unclear, recognition of postoperative peripheral sterile infiltrates is essential for managing these patients. Appropriate and early management with intense topical steroids usually results in a rapid disappearance of the infiltrates without affecting the outcome. Short Abstract Marginal or peripheral sterile corneal infiltrates are localized, noninfectious inflammatory processes of the ocular surface with various etiologies, including postoperative complications of refractive surgeries. These infiltrates may result from local immune reactions triggered by flap creation, laser ablation, and other ocular or systemic factors. Clinically, the condition presents gradually, typically between the first and fifth postoperative days, with mild or no symptoms and minimal impact on visual acuity. Bilateral involvement can occur if both eyes are operated on the same day. Although the underlying mechanism remains unclear, early recognition is critical for prompt management. Intense topical corticosteroids are usually effective, leading to a rapid resolution of the infiltrates without compromising surgical outcomes. This highlights the importance of monitoring patients for this rare but manageable complication after refractive procedures.

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Marginal Sterile Corneal Infiltrates After LASIK and Corneal Procedures

  • Renato Ambrósio,
  • Ramon Hallal,
  • Isaac Ramos,
  • Fernando Faria-Correia,
  • Louise Pellegrino Gomes Esporcatte

摘要

Marginal or peripheral sterile corneal infiltrates are localized, noninfectious inflammatory processes of the ocular surface that can be associated with several etiologies. There are reports of sterile corneal infiltrates after various refractive procedures. Local immune reactions and a mixture effect of the flap creation and laser ablation on the cornea, associated with other ocular surface and/or systemic factors, can trigger this complication. The patients typically have a sluggish onset of the clinical signs with mild to lack of symptoms because of the gradual evolution of the infiltrates. Usually, the condition presents from the first to the fifth day after the surgery; visual acuity is not severely affected, and the condition affects both eyes if operated on the same day. Although the exact mechanism of this complication remains unclear, recognition of postoperative peripheral sterile infiltrates is essential for managing these patients. Appropriate and early management with intense topical steroids usually results in a rapid disappearance of the infiltrates without affecting the outcome. Short Abstract Marginal or peripheral sterile corneal infiltrates are localized, noninfectious inflammatory processes of the ocular surface with various etiologies, including postoperative complications of refractive surgeries. These infiltrates may result from local immune reactions triggered by flap creation, laser ablation, and other ocular or systemic factors. Clinically, the condition presents gradually, typically between the first and fifth postoperative days, with mild or no symptoms and minimal impact on visual acuity. Bilateral involvement can occur if both eyes are operated on the same day. Although the underlying mechanism remains unclear, early recognition is critical for prompt management. Intense topical corticosteroids are usually effective, leading to a rapid resolution of the infiltrates without compromising surgical outcomes. This highlights the importance of monitoring patients for this rare but manageable complication after refractive procedures.