This study explores the efficacy of screw-glued joints in structural composite lumber (SCL) for creating prefabricated hollow floor systems, focusing on mass plywood panels (MPP) as a material-efficient alternative to traditional mass timber panels (MTP) for long-span applications. A series of 36 push-out tests were conducted to assess the load-bearing capacity and displacement behavior of MPP-based shear connections, comparing screw-only, glue-only, and screw-glued connection types. The experiments also investigated the impact of screw spacing (150, 200, and 250 mm) and screw types (partially and fully threaded self-tapping screws, STS) on connection performance, alongside evaluating two types of polyurethane structural adhesives. Results showed a significant increase in connection stiffness by 218% for screw-only connections using fully threaded STS over those with partially threaded STS, with load capacities ranging from 19 to 24 kN. Glue-only connections exhibited superior performance, with an average load capacity of 74 kN and stiffness of 102 kN/mm, suggesting that the pressure from STS is sufficient for adhesive curing, evidenced by 100% wood failure in the bond line. Screw-glued connections showed a modest improvement in load capacity and stiffness, approximately 15 and 2% higher than glue-only connections, respectively. The study found limited impact from screw spacing and adhesive type on connection performance, concluding that screw-gluing is a viable method for developing hollow floor systems in SCL applications, offering high composite efficiency.