Ultra-wideband (UWB) antennas have emerged as a promising technology in the field of medical imaging and sensing due to their unique ability to operate over a broad frequency spectrum with low-power consumption and high spatial resolution. This chapter provides the design, implementation, and application of UWB antennas specifically tailored for non-invasive medical diagnostics. Emphasis is placed on their role in microwave imaging for early cancer detection, such as breast tumor localization, and in vital sign monitoring systems, including heart rate and respiration tracking. The abstract also highlights key challenges associated with miniaturization, patient safety, and signal penetration in biological tissues, along with potential solutions through advanced materials and fabrication techniques. With their compact size, low profile, and high accuracy, UWB antennas offer a significant advantage for real-time, wearable, and implantable medical devices, paving the way for more accessible, efficient, and accurate healthcare diagnostics. is dedicated to ultra-wideband (UWB) antennas, which have become a key technology for medical imaging and sensing. The chapter discusses the principles of UWB antennas, their design considerations for imaging and sensing devices, and their role in advancing medical diagnostics. The antenna proposed in this chapter shows good performance and may be useful for medical and imaging applications.